Associate Professor Catherine Orrell

Associate Professor Catherine Orrell is a clinical pharmacologist and HIV physician who has been working with HIV-infected patients in clinical trials and observational cohorts since 1997. She leads the Groote Schuur Clinical Research Site (GSH-CRS), the DTHC Clinical Trials Unit and the DTHC Gugulethu Research Offices. She has been principal and co-investigator on more than 25 clinical trials of antiretroviral drugs and vaccines, including a range of efficacy, toxicity and dosing studies, both pharmaceutical and investigator driven. Her particular research interests are in HIV clinical pharmacology, ART as treatment, adherence/retention in care and resistance to ART. She has an extensive publication record in these fields.

Prof. Orrell is line manager of Senior Researcher, Dr Richard Kaplan, and Senior Medical Officer Dr Sheetal Kassim. Dr Kaplan manages Sr Alicia James, and provides additional senior clinical oversight for treatment studies and heads the Key Populations Division at the DTHF. Dr Sheetal Kassim provides additional clinical oversight for the prevention studies. Sr Alicia James manages the GSH-CRS coordinator (Sr Doerieyah Reynolds), the senior pharmacist and laboratory manager as well as the treatment study coordinators. At the GRO Associate Professor Orrell manages a smaller multidisciplinary team (Figure 2) overseen by the site investigator, Dr Lauren Jennings who provides clinical oversight for the community studies; and who manages the study coordinators. They in turn manage the Community Research Workers; a team comprised of eight lay women from the local community who have research skills supporting completion of informed consent processes, data collection and entry, as well as study recruitment and retention.